LB-456088-2 CLINICAL IMPACT OF A UNIVERSAL REMOTE MONITORING PLATFORM FOR ICD AND CRT-D FOLLOW-UP FROM A LARGE REAL-WORLD REGISTRY

Remote monitoring (RM) is standard of care for patients with cardiac implantable electronic devices (CIEDs). Questions remain regarding data management and whether RM affects clinical outcomes. This study aims to evaluate the real-world impact conventional vendors’ solutions versus a universal platform (ImplicityTM), using French national health database. Medico-administrative on patients’ characteristics, hospitalizations deaths in population across 10 years were collected. All ICD (including CRT-D) considered labelled depending type follow-up (all-RM, no-RM, ImplicityTM RM, RM) during year 2019. Patients change modality excluded. We analyzed outcomes (all-cause mortality, number cumulative duration all-cause hospitalizations) according (all-RM vs RM), different statistical methods, after considering potential confounders (age, gender, CIED type, implant). Study cohort consisted 76,418 CRT-D 24,115; age 67.6 ± 13.6 / male 78.1%). All-RM had better survival compared no-RM group (-9%, p=0.0012, Fig. 1 Left), an increased (12%, p<10-4) (7%, p<10-4). Difference remained significant mortality (-10%), was eliminated (2%) inverted (-6%) adjustment (Tab. 1). Compared associated decrease (-28%, p<10-4, Right), (-7%, p=0.0244) (-13%, p=0.0015). (-26%), similar (-7%) (-13%) Higher risk patients, identified as those chronic HF diagnosis or prior HF-related hospitalization, superior (+28%), reduction (-12%) (Tab.1). remote preliminary focused population. Further work will assess outcome pacemaker CRT-P population, extended duration. Tabled 1Comparison modalities rate, differences correction doubly robust model. (LB-456088-2)All (42581) No (33837)Implicity (5557) Conventional (35392)HRCIp-valueHRCIp-valueMortality rate (all cause mortality)ICD/CRT-D all0.90[0.80, 1.04]<10-40.74[0.65, 0.83]<10-4ICD/CRT-D higher risk0.89[0.85, 0.95]<10-40.72[0.64, 0.85]<10-4Number hospitalizationsICD/CRT-D all1.02[0.96, 1.08]0.100.93[0.86, 1.00]<10-4ICD/CRT-D risk1.00[0.95, 1.04]0.930.93[0.87, 0.99]<10-4Cumulated (in days)ICD/CRT-D all0.94[0.89, 1.00]<10-40.87[0.78, 0.97]<10-4ICD/CRT-D risk0.95[0.89, 0.97]<10-40.88[0.79, 0.98]<10-4 Open table new tab